Beta-Caryophyllene: What is so special?

CBD is only one of the benifital compounds found in Cannabis. There are other compounds that provide a synergistice response when used with CBD and provide the user with as much of the benefits as possible when using cannabis.

Today I want to talk about essential compound of the cannabis plant, beta-caryophyllene. This amazing Terpene has therapeutic properties and reacts with the endocannabinoid system similarly to how a cannabinoid would.

Beta-caryophyllene (sometimes written just caryophyllene or β-caryophyllene) is thought to have many therapeutic properties like:

  • Anti-inflammatory 
  • Analgesic (pain relief) 
  • Reduces anxiety and depression[ii] 
  • Kills bacteria and slows down their growth 
  • Kills fungi and slows down their growth 
  • Prevents cancer growth[iii] 
  • Protects the central nervous system[iv] 
  • Relieves gastrointestinal problems 
  • Antioxidant


β-caryophyllene, like CBD, binds to the CB2 receptors found in the immune system, so this terpene may also be considered a cannabinoid because of its activation of the endocannabinoid system’s CB2 receptors.

β-caryophyllene is potentially one of the most important terpenes contributing to the entourage effect of cannabis products. β-caryophyllene is nonpsycoactive and can be found in small quantities in most edible herbs like oregano as well as cinnamon, black pepper, hops. However, β-caryophyllene is found most abundantly and the cannabis plant.




1. Bonnie Goldstein. (2016). Cannabis Revealed: How the World’s Most Misunderstood Plant is Healing Everything from Chronic Pain to Epilepsy. Los Angeles, CA. Bonni S. Goldstein MD INC.

2. A Bahi, et al. (2014). β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Retrieved from The National Center for Biotechnology Information.

3. SS Dahham, et al. (2007). The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllene from the Essential Oil of Aquilaria crassna. Retrieved from The National Center for Biotechnology Information.

4. HJ Chang, et al. (2013). Protective effect of β-caryophyllene, a natural bicyclic sesquiterpene, against cerebral ischemic injury. Retrieved from The National Center for Biotechnology Information.

5. J Gertsch, et al. (2008). Beta-caryophyllene is a dietary cannabinoid. Retrieved from The National Center for Biotechnology Information.

6. Herbal Amy and CBD School (2018). Beta-Caryophyllene: A Terpene That Acts Like CBD?